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A New Module for Quantitative Evaluation of Repellent Efficacy Using Human Subjects

Jerome A. Klun, Mustapha Debboun
DOI: http://dx.doi.org/10.1603/0022-2585-37.1.177 177-181 First published online: 1 January 2000

Abstract

A new module for quantitative evaluation of arthropod repellents in human subjects was designed, constructed, and protocols for use of the module were developed. Doses of 3 arthropod repellents, 1-[3-cyclohexen-1-ylcarbonyl] piperidine (AI3-35765), 1-[3-cyclohexen-1-ylcarbonyl]-2-methylpiperidine (AI3-37220), and N, N-diethyl-3-methylbenzamide (deet), were evaluated using the mosquito, Anopheles stephensi Liston. Biting responses to varied doses of the repellents on human skin were quantified, and the effectiveness of the 3 repellents was compared. The new module consists of 6 test cells and permits the simultaneous comparison of up to 5 repellent doses or chemical types and a control using a complete randomized block design with minimal treatment interaction and with ≥6 replicates per human subject.

  • Anopheles stephensi
  • 1-[3-cyclohexen-1-ylcarbonyl] piperidine
  • 1-[3-cyclohexen-1-ylcarbonyl]-2-methylpiperidine
  • N
  • N-diethyl-3-methylbenzamide
  • new module
  • repellents
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