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Acute Toxicity Studies of Safer and More Effective Analogues of N,N-Diethyl-2-Phenylacetamide

A. Garud, Anshoo Gautam, K. Ganesan, Pravin Kumar, Shri Prakash, P. C. Jatav, Abdesh Kumar, R. Vijayaraghavan
DOI: http://dx.doi.org/10.1603/ME10236 1160-1166 First published online: 1 November 2011


The present work was designed to evaluate the toxicity of various synthesized aromatic amides that are analogs of N,N-diethyl-2-phenylacetamide, a well known insect repellent. The toxicity profile of these compounds was compared with N,N-diethyl-2-phenylacetamide as well as other registered insect repellents namely N,N-diethyl-3-methyl benzamide and N,N-diethylbenzamide. The primary skin irritation index values of the compounds, dermal toxicity of the chemicals and acute oral toxicity data to assess the safety of the synthesized aromatic amides are reported in this paper. Results of hematological and biochemical studies of these analogues are reported and discussed.

  • toxicity
  • insect repellent
  • aromatic amides
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